In addition, phytoestrogen exposure has been shown to alter breast development Figure 2; Appendix 1 <a href=http://propecia.one>finasteride</a> Upregulated SMYD2 in Pkd1 mutant renal epithelial cells a methylates STAT3, leading to its activation and cystic renal epithelial cell proliferation; b methylates the p65 subunit of NF ОєB, leading to its activation, which represses cystic renal epithelial cell apoptosis; c methylates p53, leading to the repression of p53 and cystic renal epithelial cell apoptosis; and d methylates histones to regulate the transcription of the SMYD2 target gene Ptpn13, a protein of the PTP family, which may regulate the phosphorylation and activation of ERK, mTOR, Akt, and Rb signaling |
