everything I have ever read states what I claimed, it may be outdated and I m searching now but I m yet to come across a study to show this I think the whole tamox upregulates the PgR receptor theory came from studies done on females with breast cancer who were taking massive doses of tamox <a href=http://cials.yachts>buy cialis</a> I believe one should make their way up 750, to 1000 to 1200 to 1500 and so on slowly thru cycles