<a href=http://lasix.autos/>lasix for hypertension</a> an agonist, antagonist, peptidomimetic, protein, peptide, nucleic acid, small molecule, or other drug candidate comprising the steps of i obtaining a pre administration sample from a subject prior to administration of the agent; ii detecting the level of expression of one or more selected markers of the invention in the pre administration sample; iii obtaining one or more post administration samples from the subject; iv detecting the level of expression of the marker s in the post administration samples; v comparing the level of expression of the marker s in the pre administration sample with the level of expression of the marker s in the post administration sample or samples; and vi altering the administration of the agent to the subject accordingly